ALEXANDER
KEIL
on your right

Current interests

Making sense of exposure through time. How can we ask sensible, policy relevant questions about the effects of exposures that vary over time?

My research focuses on innovating our approaches to estimating of the impact of workplace and environmental exposure on human health. Austin Bradford Hill once proposed that a way to help distinguish causality from correlation in exposure-disease relationships was if exposures were specific: when only single types of health outcomes resulted from exposure to a health hazard. In contrast, many of the things we are exposed to in the air, water, food, and workplace are potentially related in a variety of ways to human health an illness. Some of my concurrent work is focused both on simplifying approaches to addressing questions about complex exposure mixtures and simplifying communication about how single exposures may affect many diseases or competing risks.

My dissertation work was focused on methods to address Healthy Worker Survivor Bias, a well-known -- yet difficult to control -- threat to validity in studies of the health impacts of occupational exposures. This work informs policy choices such as permissible exposure limits in the workplace, as well as the quantification of disease risks among the broader population.

Public health planning: what would be the impacts of population wide exposures?


Informing interventions: How would health improve if we could eliminate exposure?

Previously, I have focused on the environmental epidemiology of autism spectrum disorders and health effects of land-application of sewage sludge. My Master's thesis, completed at The University of North Carolina, Chapel Hill was an application of Bayesian methods to correct for exposure misclassification of pesticide exposure in a case-control study of autism spectrum disorders.

Leveraging the data we have: how can we extract simple structures from complex data to best leverage limited data?

Leveraging the knowledge we have: How can we most efficiently arrive at an answer that integrates our prior knowledge with data?

 

A list of recent publications and presentations can be found on my CV here (PDF)